Functional regulation of tissue plasminogen activator on the surface of vascular smooth muscle cells by the type-II transmembrane protein p63 (CKAP4)
We have demonstrated that tissue plasminogen activator (tPA) binds specifically to human
vascular smooth muscle cells (VSMC) in a functionally relevant manner, both increasing
plasminogen activation and decreasing tPA inhibition (Ellis, V., and Whawell, SA (1997)
Blood 90, 2312-2322; Werner, F., Razzaq, TM, and Ellis, V.(1999) J. Biol. Chem. 274, 21555-
21561). To further understand this system we have now identified and characterized the
protein responsible for this binding. Rat VSMC were surface-labeled with 125 I, and cell …
vascular smooth muscle cells (VSMC) in a functionally relevant manner, both increasing
plasminogen activation and decreasing tPA inhibition (Ellis, V., and Whawell, SA (1997)
Blood 90, 2312-2322; Werner, F., Razzaq, TM, and Ellis, V.(1999) J. Biol. Chem. 274, 21555-
21561). To further understand this system we have now identified and characterized the
protein responsible for this binding. Rat VSMC were surface-labeled with 125 I, and cell …
