Structure and function of phosphoinositide 3-kinases
MP Wymann, L Pirola - Biochimica et Biophysica Acta (BBA)-Molecular and …, 1998 - Elsevier
Phosphoinositide kinases (PI3Ks) play an important role in mitogenic signaling and cell
survival, cytoskeletal remodeling, metabolic control and vesicular trafficking. Here we
summarize the structure–function relationships delineating the activation process of class I
PI3Ks involving various domains of adapter subunits, Ras, and interacting proteins. The
resulting product, PtdIns (3, 4, 5) P3, targets Akt/protein kinase B (PKB), Bruton's tyrosine
kinase (Btk), phosphoinositide-dependent kinases (PDK), integrin-linked kinase (ILK) …
survival, cytoskeletal remodeling, metabolic control and vesicular trafficking. Here we
summarize the structure–function relationships delineating the activation process of class I
PI3Ks involving various domains of adapter subunits, Ras, and interacting proteins. The
resulting product, PtdIns (3, 4, 5) P3, targets Akt/protein kinase B (PKB), Bruton's tyrosine
kinase (Btk), phosphoinositide-dependent kinases (PDK), integrin-linked kinase (ILK) …
