[HTML][HTML] Zebrafish Dkk3a protein regulates the activity of myf5 promoter through interaction with membrane receptor integrin α6b

CY Fu, YF Su, MH Lee, GD Chang, HJ Tsai - Journal of Biological …, 2012 - ASBMB
Myogenic regulatory factor Myf5 plays important roles in muscle development. In zebrafish
myf5, a microRNA (miR), termed miR-3906 or miR-In300, was reported to silence dickkopf-3-
related gene (dkk3r or dkk3a), resulting in repression of myf5 promoter activity. However, the
membrane receptor that interacts with ligand Dkk3a to control myf5 expression through
signal transduction remains unknown. To address this question, we applied
immunoprecipitation and LC-MS/MS to screen putative membrane receptors of Dkk3a, and …