Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
I Issemann, S Green - Nature, 1990 - nature.com
I Issemann, S Green
Nature, 1990•nature.comWe have cloned a member of the steroid hormone receptor superfamily of ligand-activated
transcription factors. The receptor homologue is activated by a diverse class of rodent
hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome
proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic
effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to
man.
transcription factors. The receptor homologue is activated by a diverse class of rodent
hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome
proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic
effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to
man.
Abstract
We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man.
nature.com