[HTML][HTML] The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by …
R Schietke, C Warnecke, I Wacker, J Schödel… - Journal of Biological …, 2010 - ASBMB
Hypoxia has been shown to promote tumor metastasis and lead to therapy resistance.
Recent work has demonstrated that hypoxia represses E-cadherin expression, a hallmark of
epithelial to mesenchymal transition, which is believed to amplify tumor aggressiveness. The
molecular mechanism of E-cadherin repression is unknown, yet lysyl oxidases have been
implicated to be involved. Gene expression of lysyl oxidase (LOX) and the related LOX-like 2
(LOXL2) is strongly induced by hypoxia. In addition to the previously demonstrated LOX, we …
Recent work has demonstrated that hypoxia represses E-cadherin expression, a hallmark of
epithelial to mesenchymal transition, which is believed to amplify tumor aggressiveness. The
molecular mechanism of E-cadherin repression is unknown, yet lysyl oxidases have been
implicated to be involved. Gene expression of lysyl oxidase (LOX) and the related LOX-like 2
(LOXL2) is strongly induced by hypoxia. In addition to the previously demonstrated LOX, we …
